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KMID : 1094020140310050435
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Journal of Veterinary Clinics
2014 Volume.31 No. 5 p.435 ~ p.438
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Medullary Thyroid Carcinoma in a Maltese Dog
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Hyun Hee-Jin
Jung Soo-Kyo
Kim Jae-Hoon
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Abstract
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An 11-year-old, 2.67 kg female Maltese dog with 3 weeks history of palpable cervical mass near tracheawas submitted to a local animal hospital. Radiography and ultrasonography showed radiopaque mass adjacent tracheaand vagus nerve. Surgically excised mass was solitary and approximately 3.5 × 2 × 0.8 cm in size. Histopathologically,there were large neoplastic foci admixed with normal thyroid tissues. These neoplastic foci were composed of smallto large packets of the neoplastic cells with plasmacytic morphology, and these packets were divided by fine fibrovascularsepta. Immunohistochemically, most neoplastic cells in the thyroid mass showed positive reactions forcytokeratin (AE1/AE3), chromogranin A, neuron specific enolase (NSE) and the negative reaction for vimentin. Basedon the gross, histopathologic and immunohistochemical characteristics, this dog was diagnosed as medullary thyroidcarcinoma.
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KEYWORD
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chromogranin A, dog, immunohistochemistry, medullary thyroid carcinoma, NSE
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